Maria A. Landin
University of Oslo, Norway
Title: Mapping the global gene expression during tooth development may provide new bio-therapeutics tools in dentistry
Biography
Biography: Maria A. Landin
Abstract
Tooth Development in murine models occurs in a short time-span providing a window of genetics events and is a good model for organ development. Understanding the genetic processes that govern tooth development by mapping the global murine mRNA transcriptome and their regulators miRNAs may provide new bio-therepeutic tools in dentistry. Previous research focus has been on identifying one or more target proteins that can be used as a diagnostic tool and to find the most successful treatment. The understanding of the genetic events during murine tooth development may provide bio-tools for dentists and influence positively the clinical outcome in persistent infectious cases like periodontitis or perio-implantitis. For many patients with persistent infectious conditions with loss of bone and eventually loss of teeth may benefit of new treatment approaches. Extrapolation of genetic studies may contribute to increase knowledge on the numerous biological events in regeneration and healing processes of oral soft and hard tissues may generate new treatment strategies and give predictable results in restoration treatment after oral infections resistant to clinical treatment.