Sai Kalyan
Pravara Institute of Medical Sciences, India
Title: revascularization and regenerative strategies in Endodontics
Biography
Biography: Sai Kalyan
Abstract
We stand on the world of revolution in Endodontics: Understanding, Treating and Ultimately preventing the causes of Pulpal disease. But medical revolution only happens when there is paradigm shift in interventional strategies from replacement towards regeneration. We did it for cancer, we are doing it for Alzheimer’s….can we do it for the diseased Pulp? Cell transplantation is the most established practice in regenerative medicine. It does not always obtain the good result because of the low survival rate of transplanted cells. In addition, the use of ex vivo manipulated cell products faces many translational hurdles in treating non-vital disease. Recently, the body cells are focused as a potential source for therapeutics. Some researchers have demonstrated that endogenous stem cells may be recruited to a desired anatomic site pharmacologically. This is spurring interest in developing new generation of biomaterials that incorporate and release selected powerful extracellular influences in a near-physiological fashion, and subsequently capture endogenous cells and influence their fates for regeneration. The use of patient-derived products such as platelet-rich preparations that contain a multitude of endogenous growth factors and proteins is a clinically translatable biotechnology for this proposes. These simple and cost efficient procedures may have a potential impact in reducing the economic costs for standard medical treatments in Regenerative Endodontics. OBJECTIVES 1. To understand the basic principles behind regenerative aspects in Endodontics and Periradicular surgeries 2. Deliver In depth knowledge of platelet derived regenerative modalities 3. To understand the importance of growth factors in regenerative dentistry 4. Provide applied knowledge about the preparation of first and second generation platelet derived modalities 5. To understand the role of scaffolds in revascularization/regeneration 6. Practical application of the various bench top preparation techniques 7. Importance of coronal seal and methods of achieving it using MTA (including material aspects.) 8. To give an in-depth understanding in the areas of • Stem cell treasure for Engineering Pulp-Dentine complex • Embryonic stem cells & Postnatal stem cells • DPSC(Dental pulp stem cells) • SHED (Stem cells from human exfoliated deciduous teeth) • Stem Cells from Apical Papilla • Stem cells from Periodontal ligament • Isolation of stem cells & Cryopreservation • Role of growth factors in activating tissue engineering • Scaffold effect • Bioroot formation a permanent replacement to implants