S. Sai Kalyan
Pravara Institute of Medical Sciences, India
Title: Revascularization and regenerative strategies in Endodontics
Biography
Biography: S. Sai Kalyan
Abstract
We stand on the world of revolution in Endodontics: Understanding, Treating and Ultimately preventing the causes of Pulpal disease. But medical revolution only happens when there is paradigm shift in interventional strategies from replacement towards regeneration. We did it for cancer, we are doing it for Alzheimer’s….can we do it for the diseased Pulp? Cell transplantation is the most established practice in regenerative medicine. It does not always obtain the good result because of the low survival rate of transplanted cells. In addition, the use of ex vivo manipulated cell products faces many translational hurdles in treating non-vital disease. Recently, the body cells are focused as a potential source for therapeutics. Some researchers have demonstrated that endogenous stem cells may be recruited to a desired anatomic site pharmacologically. This is spurring interest in developing new generation of biomaterials that incorporate and release selected powerful extracellular influences in a near-physiological fashion, and subsequently capture endogenous cells and influence their fates for regeneration. The use of patient-derived products such as platelet-rich preparations that contain a multitude of endogenous growth factors and proteins is a clinically translatable biotechnology for this proposes. These simple and cost efficient procedures may have a potential impact in reducing the economic costs for standard medical treatments in Regenerative Endodontics.