Biography
Biography: James L Ratcliff
Abstract
Increasingly, human saliva is used as a valuable biomarker to the identification of oral and systemic diseases. Additionally, salivary biomolecules can provide powerful activators for antimicrobials in the treatment of oral malodor and oral diseases. This presentation describes the discovery and use of a pharmaceutical composition of stabilized chlorine dioxide for the treatment and prevention of oral malodor and disease wherein the composition is buffered specifically to react to salivary biomolecules of the oral cavity. A novel means of composing has been discovered wherein the activation and release of active (gaseous chlorine dioxide) from the composition a) occurs rapidly and without a measurable interval of induction, b) results from the oxidative reduction and consumption of amino acids and volatile sulfur compound precursors, and c) generates twice the available active as that generated from conventional formulations. Further, a novel means to measuring the oxidative consumption of salivary biomolecules is revealed and discussed.Implications for future use of salivary biomolecules as biomarkers of disease and oral malodor are discussed as well as implications for future research of using the measurementof the consumption of salivary biomolecules by antimicrobials in disease diagnosis and treatment.
